Foto Otto Loewi Bildtext: Otto Loewi (1873 – 1961). German-born American physician and pharmacologist. Affiliation at the time of the award: Graz University, Graz, Austria. Photo Bilder I Syd.
Foto Henry Dale Bildtext: Sir Henry Hallett Dale (1875 – 1968). English pharmacologist and physiologist. Affiliation at the time of the award: National Institute for Medical Research, London, UK. Photo Bilder I Syd.
In 1914 Henry Dale found that acetylcholine generated stimuli in part of the nervous system, the parasympathetic nervous system, which has a dampening effect on heart activity and other functions. After Otto Loewi demonstrated acetylcholine’s function as a messenger between nerves and organs, Dale and other researchers refined the understanding of acetylcholine’s role in the nervous system.
In 1921 Loewi discovered the chemical transmission of nerve impulses the research of which was greatly developed by him and his co-workers in the years following, culminating ultimately in his demonstration that the parasympathetic substance («Vagusstoff») is acetylcholine and that a substance closely related to adrenaline played a corresponding role at the sympathetic nerve endings. It was for these researches that he received the Nobel Prize in 1936, jointly with Sir Henry Dale.
Source and more info: nobelprize.org
The Nobel Prize in Physiology or Medicine 1936. Nobel Prize Outreach AB 2021.